| Worried about cognitive decline over time? Emerging research suggests that tightly controlling food intake might help preserve mental acuity. By studying 160 gene variants in fruit flies and human cells, scientists found evidence that calorie restriction uniquely enhances a process vital for healthy brain aging. The key player is the OXR1 gene, previously linked to conditions such as Parkinson’s and diabetes. It assists cellular “recycling” by sorting proteins to reuse from those that the body can remove. Research links robust OXR1 activation with less inflammation and cell death over time. Calorie-restricted diets boosted OXR1 far more than other longevity genes. As lead researcher Dr. Lisa Ellerby, professor at California’s Buck Institute for Research on Aging states, “Age is the largest risk factor for brain diseases. Postponing aging could retard multiple conditions and neurological decline.” While still in the early stages of research, the findings offer clues on how lifestyle changes such as intermittent fasting may slow cognitive impairment in older people. Next steps involve identifying medications to safely activate OXR1. And tracking results for the growing number trying injectable weight loss drugs could offer further human insights. For now, maintaining a healthy caloric intake may help support cognitive vitality. |
How to get started with calorie restriction:
- Try intermittent fasting, such as the 16:8 schedule: The 16:8 intermittent fasting plan is a form of time-restricted fasting that may help with weight loss. It involves fasting for 16 hours per day and consuming all calories during the remaining 8 hours.
- Talk with your doctor about injectable weight loss drugs
- Stay physically and mentally active
Source: Excerpted from an article at https://www.medicalnewstoday.com/articles/could-cutting-calories-help-slow-brain-aging
