Beaufort High dropped its Region 8-AAA opener last week, falling to Berkeley High 27-21 in the high school football regional matchup last Friday night.
Berkeley holder Darius Douglas scored the game-winning touchdown with 1:59 remaining.
With the loss, Beaufort High dropped to 3-3 overall and 0-1 in the region.
Jeffrey Tookes led Beaufort High as he rushed 32 times for 229 yards and two touchdowns.
In other Beaufort High scoring, Omar Cummings added a rushing touchdown of his own.
Offensively, each team started slow. Following a scoreless first quarter, the two regional rivals traded a pair of touchdowns in the second period to enter halftime tied 14-14.
Beaufort High and Berkeley were deadlocked 21-21 at the conclusion of the third quarter.
The Beaufort High football team will be on the road in Charleston on Friday, Oct. 10, with kickoff set for 7:30 p.m. The Eagles will visit R.B. Stall High School for another regular-season game.